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Bupropion

Other Brand Names: Wellbutrin

Revised:4/1/2000

  Table of Contents
  • Overview
  • Side Effects and Interactions
  • Taking the Medicine
  • Special Precautions
  •   Side Effects and Interactions

    Side effects associated with Wellbutrin include headache, dry mouth, agitation, insomnia, tremor, sweating, skin rash, nausea and constipation.

    Other possible side effects include dizziness, nervousness, confusion, weight loss and blurred vision. Report any symptoms to your physician promptly.

    Certain other medications may change the metabolism of Wellbutrin: The AIDS drug ritonavir can lead to large increases in the blood levels of the antidepressant, while the antiseizure medicine Tegretol lowers blood concentrations of Wellbutrin.

    Taking antipsychotics, antidepressants, theophylline, or oral corticosteroids in combination with Wellbutrin may increase the risk of a seizure. So can sudden discontinuation of anti-anxiety pills like Ativan, Halcion or Xanax.

    Other possible interactions may occur in combination with levodopa, phenelzine and tricyclic antidepressants such as amitrityline.

    Because of a concern that ginkgo biloba could possibly make a person more vulnerable to seizures, it probably should not be taken together with drugs known to increase the risk of seizures. Antidepressants such as Wellbutrin belong in this category.

    Interactions between the herb St. John's wort and Wellbutrin are possible. Switching between antidepressants and herbal treatment calls for medical guidance (physicians can find a suggested protocol for gradual substitution of St. John's wort in Hyla Cass's book, St. John's Wort: Nature's Blues Buster).

    Animal experiments indicate that compounds that act on dopamine in the brain, such as Wellbutrin, may affect or be affected by the herb href="http://www.healthcentral.com/PeoplesPharmacy/PharmFullText.cfm?ID=20597&storytype=HerbalMon">chaste tea berry.

    Check with your pharmacist and physician to make sure Wellbutrin is safe in combination with any other medicines and herbs you take.