Suffer from sever depression since childhood, but only discovered my issues in my early 30's.  My first drug was zoloft which did absolutely wonders for me and I was quite stable for quite awhile.  However when I got pregnant, I had to get off them and   again I went into a tailspin. I  than suffered post-partum depression where you show little interest in the baby.  As I nursed her they couldn't put me on any anti-depressants as it would affect the child. For a whole year it was agony and I needed  a lot of help to raise her.   After a year of nursing I got back on to another anti-depressant, again zoloft, however it seemed to have lost its effectiveness I don't know if it was because of  the hormones due to the pregancy but I had to try several others.   Shortly after I went back to work for several years and my depression lifted substantially.    But than comes in a new supervisor who was very unpleasant, unbearable, dumped all her work on me and constantly complained I wasn't doing enough.  In my case I was actually doing a 3 person job and taking work home but it still was not good enough,   Thus making live absolutely miserable.  That again put me into a spiral, I couldn't take the abuse/harrassment, went to her office and  had a major melt down, I than quickly left the job.  All this related to this darn depression and it certainly didn't help I had an obnoxious supervisor who didn't want to work.    I have not worked since other than 1 temporary part time job which was terminated only because the company moved to another city and a work shortage.  I took that termination extremely personal and went into another downhill slide which i am still struggling with and to tell you the truth I don't know if I will ever come out of this one because as you get older the depression I find gets more severe, lasts longer and you have more frequent  episodes / melt downs because of it. If wasn't for my elderly parents helping I don't know what I would do.