I am 46 and 8 months ago I had my first PSA of 5.6. Biopsies were negative (8 samples), ultasound estimate of 35 grams. I am worried that if this is cancer this young (caucasian, negative family history) it may be very aggressive and metastasize early. Is there a better way to be sure than annual biopsies (needle in the haystack)? Further complicating this is that I took Avodart for 7 months to reduce PSA and mild symptoms and PSA only dropped to 4.8. Since Avodart usually reduces PSA by 50% has my PSA really nearly doubled to 9.6? It will take 6 months to leave my system to find out. Please help, I can hardly sleep at night due to worrying about this!


I can understand your anxiety. Personally, I would not treat your PSA with medications unless you have urinary symptoms of BPH. At your age, you would do better with Uroxatral.
There are no other ways to detect prostate cancer besides the biopsy. You may have to get another in the future. You should get a lidocaine block and have at least 12 cores taken.