Dear Dr. Motola,
My prostate has been surgically removed and radiation was given out of concern for a slowly rising PSA. After this was done, we went back to the doctor to find out the results and learned that my PSA was still rising slowly. Is there an explanation for this? I thought PSA could...


Dear Dr. Motola-
I also had a prostatectomy five years but with no radiation or other treatment. It was considered a "cure" by the surgeon. Recently I had some episodes of blood in the urine; urinalysis showed "abnormal cells" but not cancerous ones. Cystoscopy showed no signs of cancer in bladder. However, my ultrasensituve post-surgical PSA, which had been .01 previously, has started to rise: first to .59 and a month later to .93 Does your answer that a rising psa implies a spead of the prostate cancer always apply? Or could the other causes, such as inflammation, be applicable post-surgically as well? I don't know whether to process with biopsies of my urethra or radiation or to wait and see; neither does my physician. I have been using Testim and he wants to see if stopping that affects the PSA. Does testosterone replacement affect the psa, even post prostatectomy?
Sorry for the long question, but any opinion would be much appreciated.