Wednesday, May 30, 2012
Monday, June 29, 2009 Luving Wife asks

Q: was diagnosed with prostate cancer Jan 07. His PSA was 39 and his Gleason score was 7 (4+3).

My husband, 53 otherwise healty man who works out 6 days a week, was diagnosed with prostate cancer Jan 07.  His PSA was 39 and his Gleason score was 7 (4+3).  Due to spread to at least one pelvic node, the treatment was radiation and Lupron.  His last lupron was Dec. 08.  His PSA had been reduced to 0.0.  With testing every three months his level has gone from 0.0 to 0.2 to 0.7.  The docs note to us after the last test was short but stated that if after the next PSA in 3 months, the level continues to rise, we may need to consider further or additoional treatment options.  I am confused.  The doc had told us that he expected the PSA to rise and was not going to be concerned if it rose to 4.0 noting that his main concern was that it leveled off.  My husband now believes that the past two years of treatment was a complete waste of time and that he is going to die.  My questions are:  What is the normal or acceptable rate of rise in the PSA at 3 month intervals?  What might be the next treatment options? What is the survival rate.  I've read it could be 16+ years.?  Any info and direction is welcomed!!

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Jay Motola, Health Pro
12/16/10 11:27pm

Gleason 7 prostate cancer is not commonly associated with metastatic disease, although a PSA of 39 may be.  One question that comes to mind is whether additional higher grade disease was present at the time of the original biopsy. A follow-up biopsy may be a reasonable approach now as wold a bone scan o determine if there is any metastatic disease. Depending on the outcome of some of these tests, given his young age,consideration could be given to Provenge, the vaccine that helps prolong survival or denosumab. 

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By Luving Wife— Last Modified: 12/26/10, First Published: 06/29/09