Tuesday, September 16, 2014
Friday, May 30, 2008 T & L, Community Member, asks

Q: PSA fluctuating after prostate removal

My husband had his prostate removed 4.5 years ago.  His PSA has been undetectable until end of Jan 2008.  It then rose to 1.2 (confirmed with 2 tests).  His uroligist sent him to a radioligist.  We decided to wait for another PSA before undergoing radiation.  The next 2 tests (30 days apart) showed declines.  The April test again was undetectable.  Last week (May), his PSA had risen again but only to 0.126.  We have been told that once the PSA starts to climb it will continue to go up.  But yet it went down before.  Would something else cause this fluctuations?  Do we need to start the radiation now or should we wait to see if the next PSA declines?  His father died from prostate cancer, and his brother also has it as well as several males on his father's side.  He is 65 years old.

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Answers (1)
Jay Motola, Health Pro
9/ 6/10 8:52pm

Radiation therapy is one treatment that can be used for patients who are suspected to have recurrence. The problem with this treatment is that it only addresses the local area where the prostate was, and does not treat any circulating tumor cells which may be the source of the rising PSA.  Your question is somewhat confusing with regards to what your actual PSA is now, however 3 consecutive rising PSAs is evidence of a recurrence.  It is time to sit down with your Urologist and figure out the next step.

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suzmoon, Community Member
9/ 6/11 1:38pm

My husband 66, had his prostate removed 9 1/2 years ago.  After being 0.1 for 9 1/2 yrs., the latest reading is 0.8.  Should he be concerned about this?  A retest is scheduled, but still very concerned about this.  Please advise.

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By T & L, Community Member— Last Modified: 11/12/12, First Published: 05/30/08