If calutide is not effective then what is the solution.
MY father was diagnosed with prostate cancer two years back(June2007). his PSA at that time was 80.his both testes were removed by doctor.some oral medicine were given to him. After three month, the PSA came down to 6. urine flow become normal and there was no pain in his legs.after that he was taking calutide 50mg one tablet daily.in february 2009, his PSA was 33.doctor increased the calutide two times daily.in May2009 the PSA level is 44.Doctor says that calutide is now not effective.He is now having severe pains in both his legs and one vein in the left leg is thickened now. He also claims that sputum in now very much thicky,so he can not eat because of thicky sputum.Please suggest what could be the reason and suitable remedy for it.
Hi Shambhu,
Thanks for your question. Your father should check with his doctor about coming off of calutide if it is clear that it is no longer working. However, you may want to confirm that it truly is not helping; PSA level is not the only indicator that a drug is having its desired effect. In either case, a patient must not simply stop taking Calutide; it must be slowly titrated off of. There is no mention of the symptoms you're describing in the Side Effects of Casodex, but this does not rule out the possibility that they may be linked.
There are a variety of medications used to treat or slow down prostate cancer that has spread beyond the prostate. You can read more about those treatments in our section on Medications for Prostate Cancer.
Hope
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shambhu
Thursday, June 04, 2009 at 03:34 AM
sir, very very thanks for your good comments.in my previous querry, i forget to mention some of the things. may be that these informations help you to conclude.
testes removed in july2007, after that PSA was 6. prostate cancer of grade 6 was detected in biopsy, but doctor did not remove prostate, only testes(both) removed.before removal PSA was80. he was on calutide50mg daily.
In feb2009,there was some inflamation and pain in and around the area of surgery. a vein in left leg becomes thick and there was pain in the leg.some medical examination report of that time is like this
PSA 30.535ng/ml, Hb 6.8,WBC15,100/cumm,observed ESR 61mm/1st Hr,corrected ESR 17/1sthr,total RBC count3.5mill./cumm, Kinetic SAP 754.8 IU/L.In old units 37.84 KAunit/dL
After seeing this report, doctor increased the calutide dose to one tab two times daily.
in May2009, the same medical examination was repeated. the report is like this
PSA 44.348ng/ml, Hb 8.4,WBC11,600/cumm,observed ESR 60mm/1st Hr,corrected ESR 24/1sthr, Kinetic SAP 342.5 IU/L.In old units 17.23KAunit/dL
The alkaline phosphatase has decreased by half in three months by the increase of calutide dose but PSA has increased from 30 to 44 in three months The hb has increased from 6.8 to 8.4 but the ESR is still high, there is no change in the ESR value.
1:I want to know that can it be concluded that calutide is not effective?
2:Can it be that increase in PSA is due to high value of ESR?
3: what are the known after effects of such a surgery of testes removal? there is no problem of urine flow and passage.The only problem is of inflamation in the surgical area and thickening of veins in leg. is it known after effct? what could be the treatment for this.
4: will you advice the dose of calutide three times a day, each of 50mg?
Please examine the results and give me the proper advice. i am in a very remote area where such an experts are not avavlable. Your suggestion will highly apreciable for me.
thanks a lot.