my father (71yr) was diagnosed with prostate cancer of grade3+3=6 two years back.

testes removed in july2007, after that PSA was 6. prostate cancer of grade 6 was detected in biopsy, but doctor did not remove prostate, only testes(both) removed. before removal PSA was 80. he was on calutide50mg daily. 

In feb2009,there was some inflamation  and pain in and around the area of surgery. a vein in left leg becomes thick and there was pain in the leg. some medical examination report of that time is like this

PSA 30.535ng/ml, Hb 6.8,WBC15,100/cumm,observed ESR 61mm/1st Hr,corrected ESR 17/1sthr,total RBC count3.5mill./cumm, Kinetic SAP 754.8 IU/L.In old units 37.84 KAunit/dL

After seeing this report, doctor increased the calutide dose to one tab two times daily.

in May2009, the same medical examination was repeated. the report is like this

PSA 44.348ng/ml, Hb 8.4,WBC11,600/cumm,observed ESR 60mm/1st Hr,corrected ESR 24/1sthr, Kinetic SAP 342.5 IU/L.In old units 17.23KAunit/dL

 The alkaline phosphatase has decreased by half in three months by the increase of calutide dose but PSA has increased from 30 to 44 in three months The Hb has increased from 6.8 to 8.4 but the ESR is still high, there is no change in the ESR value.

1:I want to know that can it be concluded that calutide is not effective?

2:Can it be that increase in PSA is due to high value of ESR?

3: what are the known after effects of such a surgery of testes removal? there is no problem of urine flow and passage.The only problem is of inflamation in the surgical area and thickening of veins in leg. is it known after effct? what could be the treatment for this.

4: will you advice the dose of calutide three times a day, each of 50mg?

Please examine the results and give me the proper advice. i am in a very remote area where such an experts are not avavlable. Your suggestion will highly apreciable for me.

thanks a lot.