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Hi Shambhu,   Thanks for your question.  Your father should check with his doctor about coming off of calutide if it is clear that it is no longer working.  However, you may want to confirm that it truly is not helping; PSA level is not the only indicator that a drug is having its desired effect.  In either case, a patient must not simply stop taking Calutide; it must be slowly titrated off of.  There is no mention of the symptoms you're describing in the Side Effects of Casodex, but this does not rule out the possibility that they may be linked.   There are a variety of medications used to treat or slow down prostate cancer that has spread beyond the prostate.  You can read more about those treatments in our section on Medications for Prostate Cancer.   Hope