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Q: what is the next treatment for metasticized prostatic cancer after Lupron stops working?
If the PSA starts to rise when using Lupron, then you have developed hormonally resistant prostate cancer. An evaluation needs to be undertaken to determine if there are any sites of distant metastasis or whether this is just a biochemical recurrence. If you have not been on a complete androgen blockade the first step would be to add an anti-androgen such as Casodex (bicalutamide),however if you have been using this drug, then holding it (withdrawal therapy) is the next step and then the PSA rechecked. In addition there are a group of newer treatment for hormonally resistant disease such as Provenge, Jevtana and Abiraterone.
If the PSA starts to rise when using Lupron, then you have developed hormonally resistant prostate cancer. An evaluation needs to be undertaken to determine if there are any sites of distant metastasis or whether this is just a biochemical recurrence. If you have not been on a complete androgen blockade the first step would be to add an anti-androgen such as Casodex (bicalutamide),however if you have been using this drug, then holding it (withdrawal therapy) is the next step and then the PSA rechecked. In addition there are a group of newer treatment for hormonally resistant disease such as Provenge, Jevtana and Abiraterone.
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