My mother had had RA for 10 years.  She was on Celebrex until she developed artial fibrillation.  She then went to Remicade for a couple years and then started getting fungal sinus infections.  They said this was caused from the Remicade and that class of medications.  They said this was a serious infection so she cannot be on any of those medications.  She has been on methotrexate for the 10 years too but has had kidney damage when the dose is too high.  She was on 4 and now the dr wants to increase it to 5 and possibly up till 8.  The dr. said this is her only chose for medication now with a pain killer.  I can't believe there is not another choice for her with all the new meds coming out all the time.  Can someone help me.  She has to be on something due to the crippling effects and pain.