Living 7 years now with RA.

I am at my whits end with this disease! I have tried every biologic except Rutaxin. Doctor wants me to stay on the Orencia 1250mg for a few more months to see is it is going to work. But the few months have turned into a year and two months I have now taken the drug. In addition, I take Methoterate 2.5cc injection weekly, prednisone 5mg daily, and solu cortef (prednisol) 50mg monthly. So the prednisone has really made me gain weight. Over 80lbs in two years. I assume that I would be feeling better by now but I don't. My hands and feet hurt so bad. I can barely function to type or walk. The fatigue and flu like feelings never go away. My blood work is totally off. I test positive for the RA factor. My C reactive Protein is sky high. So the doctor has to see that I have inflammation in my body. My question is should I talk my doctor into letting me try Rituxin? I am scared to take the drug do to some fatal side effects. It would mean less time at the hospital though. I also thought about trying clinical trials. But my luck I would get a placebo or have a severe reaction to the trial drug. Im just really tired of all this pain.