I am involved with this study.  I have been receiving this medication for almost 2 years.  Back history:  I was diagnosed with JRA at 2 years old.  Remission from 6 till I was 26.  Since that point I have tried most medication combinations.  I have been medication resistant.  Research has been my only option for the last several years.  With this drug, I have a life again.  I can exercise.  I can tie my own shoes.  Pain isn't the first thing I think of when I wake up in the morning.  My only fear is when it does get FDA approval that it will be exorbitantly priced out of my budget.  Like most folks, I have insurance because I am disabled.  But of course when you look at your portion of the bill and it is still the price of a house payment (or rental in my case), it becomes an issue.  I can only hope that Roche has a program to assist those of us who don't have prescriptive programs that pay well to still get the med.  Otherwise I am back to the drawing board and on to another research drug and praying for no major slide back into inflammation and joint destruction.