Hello!
Not all medications work on everyone. I took Embrel for many months and it did nothing at all to help my arthritis. Now methotrexate worked wonderful for me. It cleared me up and I had almost no pain. Unfortunately, after having a liver biopsy it showed that methotrexate had caused fibrosis of my liver and I had to get off it. I am like you as far as being put on everything under the sun to try to relieve the pain. I was on Humira for a year and it worked well until I started having problems with cellulitis of the legs and swelling. I am on nothing to help now except Prednisone, anti-inflamatories, and pain meds. I suffer from alot of pain even on those drugs. I wish you the best in finding a treatment that will help you. I've been going through this for 14 yrs now.
I've been on enbrel for some months now and it has taken me very close to being "normal" again. I had ra mostly in my hands and arms but it was pretty severe. My hands were so swollen they looked like they'd been inflated by air and I could barely bend my fingers. After trying several different combinations of prednisone, methotrexate, and leflunomide my dr finally said I'd have to move up to the next stage of meds. I was first on humira which did work some but the dr was still not happy so he put me on enbrel (I've been on methotrexate since the beginning). By the fourth week on it I still really didn't see much effects and I was sooo dissappointed. But then by magic the fifth week I could see my hands were better. Now my hands are almost all the way back to normal and I have no bad pain anymore. As far as what effects I still have some joint weakness and mild pain in the morning...but that's about it. I'm ever so thankful that something worked for me. I hope it works as well for you too, maybe you'll get that good jolt of pleasant surprise like I did by the fifth week. I wish the best of luck!