Methotrexate & Prednisone

Connie Diller Community Member
  • Hi All,
    I have a couple quick questions....has anyone been on the combination of methotrexate & prednisone? I started on 10 mg of prednisone. Two months after that my Rheumatologist started me on methotrexate 3-2.5 pills once a week. Now every two week I back off 1 mg of prednisone & every 1 month I have my methotrexate increased. At the moment I'm on 6mg of prednisone(soon to be 5) & 7-2.5 Methotrexate. My inflamation goes up & down....I'm curious how high of dose has anyone been on of methotrexate? The fatigue has been getting really difficult. I work sub-teaching at the middle/high school about 3-4 days a week. By the time I'm headed home I am totally exhausted. Any hints or advice would be greatly appreciated. Thank you all for listening;) Take care & god Bless!
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Published On: March 07, 2008
9 Comments
  • Hollybgroovin
    Health Guide
    Mar. 08, 2008
    Connie, I take 10 mg of prednisone a day, and 25 mg of methotrexate every monday.  While I am in a massive flare right now, the methotrexate and prednisone have helped me dramatically.  It does take me about 3-4 days to recover from the methotrxate, but I have read much more relief on this dosage.  I hope this helps!  Good luck, and best...
    RHMLucky777
    Read More
    Connie, I take 10 mg of prednisone a day, and 25 mg of methotrexate every monday.  While I am in a massive flare right now, the methotrexate and prednisone have helped me dramatically.  It does take me about 3-4 days to recover from the methotrxate, but I have read much more relief on this dosage.  I hope this helps!  Good luck, and best wishes!
    • Connie Diller
      Mar. 08, 2008
      Holly, First thanks for replying so quickly....can I ask you? How long have you been on the prednisone? My Rheumatologist doesn't want to keep me on that because of my coumadin therapy(blood thinner), both of the prednisone & methotrexate are contraindication to the coumadin. I'm afraid of the increased swelling like I had last fall,(if I go totally...
      RHMLucky777
      Read More
      Holly, First thanks for replying so quickly....can I ask you? How long have you been on the prednisone? My Rheumatologist doesn't want to keep me on that because of my coumadin therapy(blood thinner), both of the prednisone & methotrexate are contraindication to the coumadin. I'm afraid of the increased swelling like I had last fall,(if I go totally off the prednisone). I was to the point I couldn't bend my fingers enough to hold a pen to write. Teaching is quite difficult when you can't bend your fingers Wacko yes it made me wacko!!! I don't like the weight gain because of the prednisone but I liked the relief. Doesn't it suck that you have to choose between more pain free & side effect or pain & swelling. Any how, right now I have also been dealing with being off my coumadin for short runs(5 days before dental procedures, need 3 visits to the dentist, 2 down, 1 to go) and getting daily lovenox injections in my belly. I've been doing those for 2 1/2 weeks now. I'm feeling like a pin cusion,(lovenox burns,needles aren't so bad). So i'm thinking where is the fatigue coming from....just getting tired!!! Well thank you for hearing my "whining"....today is a new day, we have -2 degrees outside here...way cold...but God has gotten me up & out of bed this morning so life is good! Thanks again...take care& God Bless!
    • Hollybgroovin
      Health Guide
      Mar. 09, 2008
      Connie, I have been on the prednisone for 3 years and have been on 5mg-20mg a day doses.  This has been one of the most beneficial medications for me.  Whenever I flair my rheumatologist ups my dosage by 10 mg for a week and I ween myself back down by 5mg a week until I am back to my normal dosage.  I am sorry to hear that you have had so much...
      RHMLucky777
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      Connie, I have been on the prednisone for 3 years and have been on 5mg-20mg a day doses.  This has been one of the most beneficial medications for me.  Whenever I flair my rheumatologist ups my dosage by 10 mg for a week and I ween myself back down by 5mg a week until I am back to my normal dosage.  I am sorry to hear that you have had so much trouble and so much pain.  Please remember that we are all hear for you.  Sometimes that is something I forget in my moments of weakness :)!  I hope you start to feel some relief soon as I am not feeling well myself and can understand the awful pain RA brings.  Keep your head up and keep us updated.   Good luck and best wishes!
  • Uveitis Hla-b27
    Jan. 10, 2016
    I was on methotrexate injections ranging from 15-25 mg weekly for about 8 years. After taking a break from it for hand surgery I developed retinal inflammation and had to be infused with solumedrol for 3 straight days, I think it was 1000 mg daily. After that, I began taking prednisone 60 mg tablets (they say 60 is as effective as 100) for a couple of months...
    RHMLucky777
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    I was on methotrexate injections ranging from 15-25 mg weekly for about 8 years. After taking a break from it for hand surgery I developed retinal inflammation and had to be infused with solumedrol for 3 straight days, I think it was 1000 mg daily. After that, I began taking prednisone 60 mg tablets (they say 60 is as effective as 100) for a couple of months until the inflammation was almost gone. I then went back on the methotrexate injections, 25 mg per week. 3 years later I am off the methotrexate and still taking 5 mg prednisone daily and hopefully still will be tapering off. I was diagnosed with Hla-b27 uveitis in 1991. For the last 3 months my eyes have been quiet. When I started the methotrexate in 2006 I was taking the pills. The nausea was so terrible I asked for injections instead. That helped a little. Methotrexate sapped all of my energy, maybe because it caused anemia? I was also taking pepcid, 20 mg to protect my stomach from the prednisone. This made absorption of folic acid and other nutrients impossible. I was prescribed 5 mg of folic acid per day, yet my levels were always too low. I have slowly come back from the side effects of my illness and the treatments for it. Maybe these anti-inflammoatory drugs side effects are better than the disease. The jury is still out for my case. I have been getting intra-ocular steroid injections for any flare-ups in my eyes as needed. I prefer those to curling up in a ball and waiting for my next dose of methotrexate. If I have to ever go back on it I will. I tried several other meds that caused problems. Cellcept made me break out in hives after the 1st dose. Cyclosporin caused my blood pressure to go sky high. Immuran caused UTI's that would not go away. I seem to get any rare side effects caused by medications. It has been a long journey. The upside of it all is I CAN STILL SEE. Good luck. I know a lady who has taken the methotrexate pills for her RA for years and has no side effect issues.
    • Lene  Andersen
      Health Guide
      Jan. 13, 2016
      Wow, you really have been put through the wringer. Really glad that the end result is that you can still see, though! Some people are side effect magnets — I’m one of them. You give me a medication and I am sure to develop some “interesting” side effects. The trick is to find a drug that’s only causes manageable side effects. The point of these meds...
      RHMLucky777
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      Wow, you really have been put through the wringer. Really glad that the end result is that you can still see, though! Some people are side effect magnets — I’m one of them. You give me a medication and I am sure to develop some “interesting” side effects. The trick is to find a drug that’s only causes manageable side effects. The point of these meds is to help you live a better life, not to limit you as much as active disease would. A lot of new medications are available now that weren’t when you first were diagnosed with uveitis. There are a lot more choices, and a lot more possibility that should you need it, you might be able to find something that you can tolerate.
  • deniw
    Aug. 13, 2011

    A young friend has started on this therapy... I am not sure that she understands the implications of taking these medications this long.  Have you been given any other information that way??  I have been reading and researching natural health ideas for years... so uncomfortable with this.

  • sarah
    Mar. 04, 2011

    Hi yes, I was on Prednisloline around  15-20mg and started on mtx 5mg I think - I am now on 20mg of mtx and 5mg of Prednisoline - the steriods helped kick start my recovery whilst the mtx takes its time to work.. Good Luck.

  • Luc Villeneuve
    Nov. 22, 2010

    Hi

     

    I have been diagnostd whit a very nasty uveitis last year and the pred treatment has not worked so i started 3 weeks ago on both drugs but i will stard cutting off the pred next week...i must say i have add no side effect at all exept a very small headach a few hour after taking the metatrex but nothing else.even whit the prednisone i have not gained...

    RHMLucky777

    Read More

    Hi

     

    I have been diagnostd whit a very nasty uveitis last year and the pred treatment has not worked so i started 3 weeks ago on both drugs but i will stard cutting off the pred next week...i must say i have add no side effect at all exept a very small headach a few hour after taking the metatrex but nothing else.even whit the prednisone i have not gained an ounce so i guess im one of the lucky few who dont have side effects. I must say that i am in top physical shape , i exercise a lot and eat very well so i guess my taking care of my body is paying off.

     

    good luck...Luc

  • Anonymous
    Sabina
    Feb. 18, 2010

    Hello...

    I have been on prednisone for 2 years, great medication. My concern is that steroids are not good for the heart so I asked my Dr. to try another med. I have been taking methotrexate for 3 months now & it is not doing what I thought it was supposed to so yesterday he told me to increase the meth to 7 2.5 per week from 5 because it takes approx....

    RHMLucky777

    Read More

    Hello...

    I have been on prednisone for 2 years, great medication. My concern is that steroids are not good for the heart so I asked my Dr. to try another med. I have been taking methotrexate for 3 months now & it is not doing what I thought it was supposed to so yesterday he told me to increase the meth to 7 2.5 per week from 5 because it takes approx. 4-6 months to kick in to do what it should be doing. Now my concern is that my heart rate is increasing to a concern level & I need to check with my cardiologist if meth & pred are conflicting. Will keep you tuned. I am also experiencing the same fatigue that you are which leads to laziness & list of things to do getting longer...etc...etc...etc.

    Have a super day!   Sabina   Cool