I have a couple quick questions....has anyone been on the combination of methotrexate & prednisone? I started on 10 mg of prednisone. Two months after that my Rheumatologist started me on methotrexate 3-2.5 pills once a week. Now every two week I back off 1 mg of prednisone & every 1 month I have my methotrexate increased. At the moment I'm on 6mg of prednisone(soon to be 5) & 7-2.5 Methotrexate. My inflamation goes up & down....I'm curious how high of dose has anyone been on of methotrexate? The fatigue has been getting really difficult. I work sub-teaching at the middle/high school about 3-4 days a week. By the time I'm headed home I am totally exhausted. Any hints or advice would be greatly appreciated. Thank you all for listening;) Take care & god Bless!