I have been taking Plaquenil for 27 days as of today. The first two weeks I hurt worse than I have ever hurt in other places before! My fingers in my joints hurt so bad it's hard to type. My knees are now hurting. For a week I forgot to take the 2nd dosage @ night, and the pain lessened. Now I have been taking them exactly as prescribed twice a day same day, and Im like a cripple!!! Im continuing to move and stay active. Not helping only more swelling and it feels as if every bone in my fingers feels sprained. Hurts to write, type, brush my hair, get dressed, drive, pick up ANYTHING heavier than a pen! I'm so frustrated!! I have my next appt on the ninth... not sure what to do til then but I know I'm gonig to continue taking the pills... just frustrated that I hurt more now that I'm taking the medicine 
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