It is now almost one month since I went in for my first infusion of Rituxan. Thinking back - that day was quite the adventure. You can read about the experience in Rituximab Infusion for RA: My First Experience, an article in which I also present a lot of information about Rituximab (Rituxan®).
The 2nd Infusion Experience
During my first infusion, I experienced cytokine-release syndrome, also known as an acute infusion reaction. It was very much unpleasant and still makes me feel itchy and swollen if I think about it (not physically, but just through the memories). Since I had been in that estimated 10% of patients who had such a prolonged reaction as to need medical intervention, we were very conservative and began cautiously for the 2nd infusion.
My rheumatologist wanted to see me after the 1st infusion, but I had already made plans to go away for the week of Thanksgiving. My beau and I went away as planned. When I returned, my doctor and I spoke. I told her that everything was going well. I felt good (which I’ll talk about in just a moment). She said that the hospital (ie. the nurse and doctor who were caring for me during the infusion) had called several times during that first infusion. As my doctor, Dr. Price had to make the decisions and give the orders on what to do for me while I was in the outpatient clinic section of the hospital.
So for the 2nd infusion, my rheumatologist ordered additional hydrocortisone to be ready for use if necessary. She even altered my pre-infusion treatment to include not only the dose of IV hydrocortisone but also IV benadryl this time. Wowsa!! That stuff is strong going directly into the vein.
Oops, I should back up in my story. After getting an IV in place, the nurse drew blood to have my blood counts checked. We would need to wait for the results to come back before getting started. I asked for copies of the test results (which the nurse happily gave me) and everything looked fine. We were good to go!!
After the blood tests came back, then we started with the pre-medication routine which included 2 Tylenol caplets, IV benadryl, and IV hydrocortisone. It was time to order up the Rituxan from the hospital pharmacy. There was a minor glitch, however, and the pharmacy was waiting on the 2nd vial of medication to arrive. The time between pre-medication and the start of the actual treatment was lengthened considerably. This was just as well, because it allowed the pre-meds to circulate thoroughly and probably be even more effective. I was in no hurry, having planned to be in the hospital for the entire workday anyways.
Once we got the infusion started, the infusion nurse monitored me carefully. When I began to experience the most subtle itching and swelling sensation, she didn’t hesitate to see if it would progress. She administered another dose of hydrocortisone and I had the easiest of infusion experiences after that. I knew what to look for, she knew what to look for, we had planned ahead and acted accordingly.