Positve Rh factor and positive HLA -B27

mdwanabe Community Member March 15, 2008
  • Curious...am HLA -B 27 positive for yrs. have osteoarthritis and countless surgeries for bone spurs and bone on bone. My neck is crumbling, especially for a 43 yr. old. Recent blood test showed an actual number on the Rheumat factor. Fortunately, it was in the normal range. My question is, does everyone have the Rheumat factor in their blood and it becomes diagnostic when the level is high? Or is having the factor in your blood suspicious of Rheuamtoid arthritis?  I'd swaer that my Rheuam factor had always read "negative". I kinda a feel like my Rheumy is not doing enough to keep me from getting worse. He just gives me anti-inflammatories. I saw my mom have a shoulder, a large metatarsal  bone and a collarbone get reabsorbed from severe arthritis which remained undiagnosed until it was too late. She had SEVERE Psorasis that got into her bones, ostoearthritis  and a weakly posisitve ANA but never heard about her RH factor. These tests were done in the early 80's and I rememeber they were thinking she had lupus because her kidneys were quitting.  I just don't want to end up like her. Her last year were spent on dialysis and oxycontin and vicodin and then dying at age 66. i remain positive, very active with work and bike riding and some weight lifting. I'm as proactive as I can ever and keep a very positive attitude. Sometimes I think my "sunny" disposition doesn't always do me justice when I see the Rheumy. I tend to downplay my pain which limits me at times and causes alot of sleep loss. 
3 Comments
  • Hollybgroovin
    Health Guide
    Mar. 15, 2008

    I am not a doctor, but I do know that the Rheumatoid Factor is a funny thing.  You can have a Rheumatoid Factor even if you don't have rheumatoid arthritis.  But then you can also have RA even if you don't have Rheumatoid Factor in your body. 

     

    http://www.healthcentral.com/rheumatoid-arthritis/c/53/15969/factor/

     this is a health...

    RHMLucky777

    Read More

    I am not a doctor, but I do know that the Rheumatoid Factor is a funny thing.  You can have a Rheumatoid Factor even if you don't have rheumatoid arthritis.  But then you can also have RA even if you don't have Rheumatoid Factor in your body. 

     

    http://www.healthcentral.com/rheumatoid-arthritis/c/53/15969/factor/

     this is a health central site that explains a little more about how the rheumatoid factor works.

     

    I happen to be one of those "lucky" people who happened to have a high positive rheumatoid factor, and a positive ANA.  I was suspected of having lupus first, but then got my final diagnosis of Rheumatoid Arthritis.  I know how frustrating it is to feel like your not getting enough treatment.  I went through 3 rheumatologists before I found one who was willing to treat my RA aggressively.  It does sound like you are proactive and have have a great attitude.  That's wonderful and I know how hard it can be to keep your head us, especially when you are losing sleep due to the pain.   Please keep us updated and let us know what your next step might be and how you are doing.  Good luck, and best wishes!

     

    Also after quite a bit of researching I found a site that show that there is a link with being HLA-B27 positive and rheumatoid arthritis.  I hope this all helps.  And please keep us updated, we are all here for support so if you have any questions or just need to vent, feel free!  

     

    http://www.springerlink.com/content/v75w72145035931l/
  • CyndiLou
    Mar. 17, 2008
    I have had RA my whole life and I seriously dont know if they've ever done a rheumatoid factor test or ANA or HLA-B 27. I don't even know what those are. I know they always take a sed-rate and it comes back different every time. I'm going to ask my rheumy about these tests just out of curiousity. I also think my girls should be tested as they have...
    RHMLucky777
    Read More
    I have had RA my whole life and I seriously dont know if they've ever done a rheumatoid factor test or ANA or HLA-B 27. I don't even know what those are. I know they always take a sed-rate and it comes back different every time. I'm going to ask my rheumy about these tests just out of curiousity. I also think my girls should be tested as they have alot of pain in their knees and back but I'm always told it's growing pains. My 17 has been in pain since she was 9 and my 10 year old started having the same pains about a year ago. The pediatrician thinks I'm paranoid. Thanks for your post because it might just get me the answers I'm looking for. Can a GP order these tests or do I have to get a referral to a rheumy?? 
    • mdwanabe
      Apr. 17, 2008

      Your GP can order these tests...he just needs to do a Rheumatology Profile which should include an ANA, ESR, CBC, HLA-B27, Rhematoid factor....maybe even an ELISA test which I think looks for Lyme disease. There is a new Anti-body test that is specific for Rheumatoid but I can't remeber the name. A CRP also is an marker that can be tested for imflammation...it...

      RHMLucky777

      Read More

      Your GP can order these tests...he just needs to do a Rheumatology Profile which should include an ANA, ESR, CBC, HLA-B27, Rhematoid factor....maybe even an ELISA test which I think looks for Lyme disease. There is a new Anti-body test that is specific for Rheumatoid but I can't remeber the name. A CRP also is an marker that can be tested for imflammation...it is a bit more sensitive than the ESR. They also can do a general HLA typing test that can indicate markers for arthritis and sometimes, if you are postive for HLA-DR4, it could indicate a more aggressive form of the disease. I am not a doctor, so do not take my words as gospel, but, I do work in a Doctor's office nad between that, my own health issues and what I went thru with my mom, I have quite a bit of information. Let me know!