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Hi Scrappy,  Ive been on metho for 5 months now and have been feeling much the same as you.  I take my 10 pills every monday and feel like crap all day.  I found if I take the metho on an empty stomach then i'm just nauseous all day.  If i take it with food, then i puke.  Needless to say- i take them on an empty stomach!!  I take other pills in the morning too and have never had a problem til I added the metho.  Yes, I agree with Lene about the stages of grief as i'm in the denial stage now.  She has some good advice in her Shareposts so definitley check them out   I asked my doctor if there was anything i could do or take to help with the nausea and he suggested splitting the times i take my dose.  So, every monday i take 5 pills in the morning and 5 pills in the evening.  This seems to make the nausea milder but doesn't take it away entirely.  I'm still nauseous and bone tired every monday- but to a lesser extent.  I can function, and keep moving and that helps me mentally.  Talk to your doctor and make sure its okay with him before you try any changes!  And good luck!