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Hi ScrapHappy, I've been on methotrexate for 2.5 months, since being diagnosed. My rheumatologist told me, as I began, to take the pills at night so I could sleep through the nausea. That has helped me a great deal. I also try to eat little bits throughout the day rather than full meals. I also take several other pills (for pain, thyroid, aspirin, allergies), as well as a LOT of supplements (have for a long time). Having to add on the RA meds has not been easy, but have found I just have to keep trying to be as positive as possible. We'll make it through this, hopefully, with the help of this good support site! Have a good day! Norma