Thursday, June 12, 2008 Monty, Community Member, asks

Q: How often should I have blood tests to determine if the Methotrexate is causing damage to my liver?

I was told that I would have to have periodic blood tests and urine samples when I began taking Methotrexate.  I have taken it for about six months and have had one blood test (after the first month) and no urine samples.  Is this normal?

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Answers (7)
Casey McNulty, Health Guide
6/17/08 6:27pm

Hi Monty,

Thanks for your question. It is recommended to have your liver function tested every 1-2 months while taking methotrexate. It is also recommended to have a CBC (complete blood count) and platelet count every month, and have your kidney function checked every 1-2 months. You can read more about methotrexate here.

Best of luck,


Lisa, Community Member
6/12/08 11:20pm

I have been taking methotrexate now for a few months. 2.5 mg tablets at 8 per week. I am new to RA so I am not sure what normal testing would be for this drug but I will tell you what I do. My rheumatologist told me to have bloodwork done monthly. However, it is my responsibility to go to the lab every month and have this done- no reminder from the doctor or the lab. If I were you I would insist upon more frequent testing. Hope this helps.

Julie, Community Member
6/17/08 11:13am

I have been on methotrexate now for quite a few years and you should have a blood test every month.  You should have a full blood count and an admin profile every month and a ESR at least every 6 months or more often.  It is your responsibiity to go to your doctors surgery every month and have this done.  Hope this helps.

lisad, Community Member
7/ 1/08 3:11pm

My doctor had me have a blood test 2 weeks after the inital starting of meth and then every 6 weeks after.  Hope this helps!

debbie, Community Member
7/11/08 11:39pm

i have been on methotrexate for a year and a half i have blood tested every 3 months i have to see my rheumatologist every 3 months no urine

TJ Maxant, Community Member
8/26/08 12:27am


Monthly is what my RA and pain mgmt drs have me do

Lee, Community Member
9/29/08 8:52am

I would say it is not normal.  My rheumatologist insisted on blood work screenings for liver and kidneys and CBC  every 3 weeks, and it's been like clockwork.  Good luck.

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By Monty, Community Member— Last Modified: 12/24/10, First Published: 06/12/08