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Hi Lori, There are several lab tests that may indicate RA.  But two of them, rheumatoid factor and SED rate are not always indicative of whether you have RA.  Having a negative rhaumatoid factor doesn't mean that a person won't have it.  Having a positive rheumatoid factor may indicate a higher probability of having a more moderate to severe disease course.  I believe a SED rate is a measure of the white count, which would indicate autoimmune activity or inflammation.  I'm RA factor negative, always have been and have never once had an elevated SED rate, yet I have RA.  I think one of the newest tests for C-reactive protein may be a better indicator.  But rheumatologists one use these lab tests as one factor in making the diagnosis.  They will also look at history, phyisical evidence of inflammation, joint pain and stiffness, family history and x-rays or MRIs.  On the other hand, the rheumatologist will also try to rule out other autoimmune disorders like lupus or fibromyalgia, etc or ailments with joint pain that can look like RA.   The RA page has a good description of the tests that are used to diagnose RA.  That may be helpful for you.  Under the 'Manage" heading at the top of this page, there is a section for tests and results.  Under the "Find" header, there is also a good symptom checker.   Best wishes to you and your family. Christine