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I have not taken the plaquinel or metatrexate. I did see a Ruematologist and I have RA. I have been taking supplements for 1 1/2 years.  I did lots of searching on line. I make a super shake in the a.m. that strengthens me and relieves a lot of pain. I take various herbs and supplements every day. I have taken gucos/ condr. by Jarrow. I took it in the a.m. with a digestive enzyne. But Cosomiine  DM seems to get great reviews by everyone I have spoken with.  Expensive but produces result in Osteoarthritis patients. Aloe vera Juice is anti inflammitory, Boswella, Pomegranate capsules too. I like a product called Arthred, I use half a scoop. Just Barley Barley green Juice powder can be put in a shake with aloe vera juice  and spirolina powder. Hydroplenish which is Hyalauronic acid, 2 capsules 1-2 times a day got rid of fluid on my elbow. Glucos/cond are sugar and sulfer that are precurser to hyalauronic acid. I take lots of stuff. I also stretch in the shower when my muscles are warm. I  also use rubs and oils. Tiger Balm linament is oil of wintergreen which reduces pain and inflamation, very different from regular tiger balm. On line you can order maharanan oil. Look under aruvedic oils. It smells good and stops pain, warm the containor in dish of warm water and use on all joints. I would suggest that you find a  Dr. who will treat you aggressively and wholistically. The Rheumatologist is concerned with giving you a quality of life. They want you to be able to work and wash the car and hold the baby. It is felt that you may not be able to do that if you take supplements.  The Rhuematologist wants to stop damage to your joints. They feel the drugs that suppress your immune system is the best way to go. You may want to do the medication until you can sort your way through the maze of info on herbs and supplements. I do get flairs and I do cry and I have some bad days. I have to watch my diet and will react to food and have to elimate any food that causes a reaction. Books to read Autoimmune Epidemic, Eat to Live by Joel Fuhrman. You can find him on Utube. After reading the book Autoimmune  Epidemic, I  decided I will do my medical check-up with traditional M.D. And I will then see a Pathologist who teaches at a major university and treat patients using alternative medicine. googling - Pain Free Rheumatoid. Remissions Rheumatoid. may be helpful. Conclusion: Best done with guidance if you want to go alternative route. Try to find an M.D. who will treat you alternatively. Check in Health food store or magazine called Alternative Health publishes a book on Arthritis. Gary Null's books have physicians listed in back of book as resources.   Please feel free to contact me at sharonbgood@mac.com sharon