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I am new to this site but I wanted to answer your question from what I have learned. I've been on Methotrexate since 2003 and I finally stopped almost 3 weeks ago as I noticed my hair was about 1/2 as thick as it use to be. It still comes out when I comb it especially after I wash it. I guess I'm self consious enough without worrying about my hair. I have long hair and many it's vanity but I can't deal with it any more.