please do not stop medication without talking to your doctor about it. There are certain RA medications that you should not stop "cold turkey" because it can bring on an extreme flare. if you are having problems with side effects, call your rheumatologist and discuss the issue. It may be an indication that you need to mess with the meds you're on, the dosage, etc. You're right that if you are having significant side effects, you need to take a look at whether the meds you're on are the right ones for you. Although a certain amount of side effects can be expected, they should be manageable, not affect your life as much as uncontrolled RA does. If side effects become unmanageable, it's time to talk to your doctor about treatment options.

You have to take a look at the pros and cons of taking the meds. Without medication, you risk permanent damage to your joints that can affect your ability in the future. As RA is a systemic disease, not having your RA controlled can also having an impact on other parts of your body such as your heart health. Diabetes may also be a comorbidity with RA, which means that people with RA have a higher risk of developing this disease. It's possible that your diabetes is not related to the Plaquenil, but to other factors, including possibly your RA.

please call your rheumatologist. And also please keep us posted on what happens.