I'll be upfront with you and say that I don't know an awful lot about nodules, but we do have an excellent interview with a rheumatologist where we asked all kinds of questions about nodules, so that might give you more information. However, I would also definitely recommend that you speak to your rheumatologist about this. You mentioned that you've been on a lot of different meds over the years, but nothing has helped - have you tried a different Biologics? Currently, there are nine different Biologics available on the market and some of them have help people who haven't had anything work before (e.g., Rituxan). Check out Lisa Emrich's series of posts on Biologics for more information.
let us know how things go, please?
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