Also, sometimes mixing drugs & alcohol may increase the metabolism time, essentially givein you a stronger or longer dose - which you may not like, or may not be good for you!  Alcohol and drugs (prescription or non-prescription) are usually metabolized by the liver, and if they both are using the same 'metabolic pathway', then it's like a traffic bottleneck, things slow down, and you may end up with too much in your blood, for a longer period of time.  If you keep this up, you can damage your liver (not to mention your stomach!)  Celebrex appears to have less risk than Bextra and Vioxx (which is why it's still around) but the risk is not zero.  I've been taking Celebrex for a long time and can't even take a lot of it. There is another benefit to Celebrex (ironically) at higher doses it reduces the risk of forming colon polyps (for those who may have the tendency to form them, or a family history of colon cancer, like me).  I used Bextra for a while, and Mobic for a while - eventually all of them gave me heartburn or stomach problems (great while it lasted, but ...) back to Celebrex.  Even with Celebrex, every once in a while I have to back off for a few days to a week to give myself a break, and then it works better anyway...