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I have been on Enbrel for about 1 year. It has helped with alot of my RA discomfort. But it seems latley I have been having very extreme mood swings, just not myself. I always chalk it up to PMS, but there is no way I have PMS every week of the month. I have not been eating more and sex drive is down. Sometimes I think it is all in my head and I should be able to control it. i am going to do some extensive research on the side effects of Enbrel and I will get back to you.