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I'm in my 9th week with Enbrel and am noticing I feel more depressed and fatigued the longer I take it....besides the consistently sore throat and sinus drainage...which could be part allergies, but seems magnified this year. I actually noticed no noticeable difference in tiredness or mood until around the 7th week. Like you, I'm hoping it will only get better, but I'm calling my doctor Monday . This is beginning to feel like no way to conduct a life. I'm seldom my happy self anymore.
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