I am in the midst of switching from prednisone to methotrexate (down to 10 mg of pred. and 2.5 mg x 4 per week of meth.)and my flare ups have been awful in the last week or so. I've been on meth. for 4 weeks now. Hands, wrists, feet and ankles are the worst. Have difficulty walking, especially in the morning, and my hands hurt all day. I am also just very rundown and tired all the time. My Dr. has advised me to apply for disability leave for 3 months while he tweaks my meds to get the RA under control. He thinks he needs to add a TNF inhibitor with the meth. Am waiting another few weeks to see if the meth alone will do the trick. I am feeling miserable but still strangely guilt-ridden about taking my Dr.'s advice and not working right now. I am sort of a perfectionist and I feel like a failure by announcing to the world that I am too sick right now to work. I would love to know if anyone else has dealt with this particular issue before.