Hi Vicki,   Lab tests are useful in helping to diagnose RA, but as you are aware, it is possible to be seronegative for Rheumatoid Factor and still be diagnosed with RA.    The Anti-CCP, or Cyclic Citrullinated Peptide (CCP) Antibody, test is used to help make a diagnosis of RA.  It is often ordered at the same time as the RF test or as a follow-up test.  Just like RA patients are not required to have elevated RF levels to be diagnosed, they also do not have to have elevated Anti-CCP levels.   The diagnosis of RA is a clinical one, meaning that it is made based on clinical signs and not laboratory tests.  The tests help to show the presence of abnormalities, but abnormal results are not required for diagnosis.   What does your rheumatologist say about the test results?  For what reason were the tests ordered?  Definitely share your questions and concerns with your doctor who is best able to help put things in perspective for your personal situation.   Lisa