So Tatiana, here is something interesting for you. I signed up for a free CME course online through MedPage Today. You can sign up for the one hour presentation as a patient or interested healthcare consumer. But the course was about the targeted approach to treating patients with RA. They were talking about the newest thoughts on how to best "treat to target" where target is remission (our holy grail!) or low disease activity if remission can't be achieved and how best to put those ideas into clinical practice. Anyway, as part of the presentation, there was a discussion of recent studies comparing the saftey of different biologics. According to their data, abatacept and anakinra have better safety profiles than the others - that's Orencia and Kineret - though I thought that Kineret wasn't used as much since it seems to be less effective except in JRA. Anyway, I think if you do some online research and look for some comarative studies, you might find some information. Or talk to your rheumatologist, they may be able to guide you here.