Friday, December 25, 2009 liz, Community Member, asks

Q: methotrexate hair loss

I have been on methotrexate for 10 years successfully with little or no side effects. Now,  I lost a third of my hair and continue to lose  it. Is it possible to start losing hair after being on the medication so long with no hair loss before? My doctor wants to change medications but i am reluctant since this has worked so well for me, especially after trying so many different meds when I first got diagnosed. I have also doubled up on folic acid but it's not working.  Any ideas or solutions?

Answer This
Answers (6)
Lene Andersen, Health Guide
12/28/09 11:52am

Yes, it is possible to develop new and "interesting" side effects after having tolerated a particular medication for a long time. We all decide what side effects we can and cannot live with and for many, hair loss is unacceptable. On the other hand, other people take it in stride and stay on the medication - you may want to check out a post from Holly, one of our Experts who wrote about her decision to continue methotrexate despite hair loss. Speak to your doctor about vitamin B12 injections, as this may help slow down hair loss or possibly help it grow back. You may also want to talk to your doctor about whether it will grow back - I've heard conflicting stories about methotrexate-related hair loss that seems to indicate that any sometimes, the hair loss is permanent and this may be a factor in your decision.


Methotrexate is on the lower rungs of the treatment ladder for RA and there are many other options for medication. Keep in mind that even if you try something else, you can always go back to methotrexate if you don't like your response to other drugs. However I would recommend that you have an in-depth discussion with you rheumatologist about the specifics of why they are recommending another form of treatment, the pros and cons of switching, etc.


Good luck! Please let us know how it goes?


1adyryder, Community Member
12/26/09 11:57am

I am not a doctor but can relate to the hair loss. I have been on methotrexate for about 2 yrs. and am seeing hair loss for the first time. lI have thin hair to begin with and this has only aggravated that condition. I finally just shaved my head and got wigs instead of trying to rearrange a few thin hairs. Friends say it takes away years! I also have a great shaped head(if I must say so) and love the "bald look" as much so, that I'd  like to start a "movement", after all, guys have been doing it for years! You might be surprised at how awesome you look!

julesinpain, Community Member
12/30/09 6:51pm

You may want to consider having your thyroid checked too.  Hair loss is a symptom of low thyroid.

Juanab, Community Member
12/31/09 4:09pm

I have been taking methotrexate for two years and was told by my rheumy it would cause hair loss.  My rheumy prescribed folic acid which I take daily, it has helped to reduce the hair loss to a small amount. 

Golden Mushroom, Community Member
1/ 2/10 2:45pm

I too have suffered with hair loss. Recently my rheum suggested I increase my folic acid to 2mg a day and this seems to be working :)

dee, Community Member
3/10/10 1:58am

i have the same problem....can't help

Answer This

We hope you find this general health information helpful. Please note however, that this Q&A is meant to support not replace the professional medical advice you receive from your doctor. No information in the Answers above is intended to diagnose or treat any condition. The views expressed in the Answers above belong to the individuals who posted them and do not necessarily reflect the views of Remedy Health Media. Remedy Health Media does not review or edit content posted by our community members, but reserves the right to remove any material it deems inappropriate.

By liz, Community Member— Last Modified: 12/26/10, First Published: 12/25/09