I have had RA for 4 years. I have tried all steriods, anti-inflammatory medications, Methotraxate, Humira, Enbrel, Orencia, and Arava with no relief. I found I am allergic to all of them. I did Rituxan in 2006, and it lasted 2 years. I had another Rituxan treatment in July 2008 and it only lasted 6 months, and I was not pain free during those 6 months. My rheumatologist is going to put me on a new drug Simponi. I have 2 questions. Is there anyone out there who is allergic to all the RA medicines available? Is there anyone who has been taking Simponi for any length of time?