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Friday, May 08, 2009 dlyn9smith, Community Member, asks

Q: Allergic to all anti-inflammatory and other RA medications, where to turn.

I have had RA for 4 years. I have tried all steriods, anti-inflammatory medications, Methotraxate, Humira, Enbrel, Orencia, and Arava with no relief. I found I am allergic to all of them. I did Rituxan in 2006, and it lasted 2 years. I had another Rituxan treatment in July 2008 and it only lasted 6 months, and I was not pain free during those 6 months. My rheumatologist is going to put me on a new drug Simponi. I have 2 questions. Is there anyone out there who is allergic to all the RA medicines available? Is there anyone who has been taking Simponi for any length of time?

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Answers (2)
Lene Andersen, Health Guide
5/20/09 11:15am

Wow, you really are in a difficult position. I do have some allergies and intolerances with certain drugs, but not to the extent you have. In terms of Simponi, it's a very new drug - has only just been approved by the FDA - so people would've been on it would have done so during the drug trials. You may want to try to answer question again in a SharePost which can give your question more exposure - I remember a few users on this site describing similar problems (but unfortunately can't remember who it was), so a SharePost may bring them out to comment with more information and tips.


Good luck!


Julie, Community Member
6/14/09 1:49am

I had my first injection of Simponi June2.  I was amazed how fast I had relief. My inflamation was deminished significantly in 2 days.  I'd say by 75%. No side effects, that I know of, so far.  I am impressed, so far. I hope that it does not wear off before 30 days. 


I hope that you find something that works for you. 


You may want to ask your dr about getting food allergy testing too. I found out that I am Gluten Intollerent and allergic to eggs.  If I eat anything with these ingredients, I get a bad flare up.  Allergies can cause inflammitory reactions.


Be well.



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By dlyn9smith, Community Member— Last Modified: 12/22/10, First Published: 05/08/09