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I have been on Cimzia for a few weeks now. I had 1 200 mg injection the 1st week because I had my Remicade infusion a few weeks earlier so I couldn't get the loading dose week 1. 2 weeks later, I took 2 of the 200 mg injections for 400 mg total. While I didn't get any relief that first week, I did feel much better after that second dose 2weeks later. I had more energy and less joint pain and didn't miss any work. This is a vast improvement as I have been treated with methotrexate, Arava, Orencia, and Remicade. The methotrexate, Arava, and Remicade increased my liver enzymes to levels that my rheumatologist felt was unsafe and, in addition I felt no therapeutic response to the methotrexate, Orencia, and after 6 or 7 months, the Remicade. I am hopeful that the Cimzia is my drug. If it increases my liver enzymes, my GI doc has decided to do a liver biopsy because this is a situation that only applies to me. It did take about 2 weeks for my insurance company to approve this drug but it did get done. I have found that I am sharper mentally.  I felt flat because of the lethargy, it was difficult to concentrate. This drug has worked very well for me so far. (I am a Registered Nurse that spends half of my day in a hospital and the other half in a Home Health office)