How bad do the side effects of Methotrexate have to be before I get concerned? I am having terrible trouble with my sinuses. I have been taking Methotrexate for just over a year now, and my nose is getting worse. I have opened sores in my nose that bleed all the time. They are like small bleeding ulcers really. It is beginning to really worry me. Is this normal? Is there anything that will help? Would a Neti Pot help? Should I stop the Methotrexate and try something else? I hate to switch med.'s. I tried Plaquenil and was allergic (broke out in a rash). I've tried salves and etc. to get my nose to heal up, but nothing seems to work. What should I do????