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I was on this it pretty much drained all of my energy to where it took every bit of energy for me to just get out of bed. I was tired of being a lab rat when they could not tell me what type of Arthritis I had so I quit cold turkey from the methotrexate and the folic acid and aspirin which has been about close to three years now but the Arthritis pain has been stronger now to where to pain feels as if it is now actually in my bones. Not a smart way to go but I just could not function that way they I was put on pain killers and muscle relaxers and that is also a bad way to do because I took my muscle relaxer one morning and totaled my car, went to jail twice and now am on probation all because of the pain and muscle relaxer medication and pretty much I have made a big mess of my early 41 age and now have probation for one person who was NEVER EVER in TROUBLE WITH THE LAW so beware of taking your medication and really even over the counter medication and driving because I found out the hard way unfortunately this is a combine problem with people dealing with pain. Pray for me and I will surely pray for you as well. God Bless you!!! BBoop