• Sandra Horn Sandra Horn
    March 15, 2010
    methotrexate not working
    Sandra Horn Sandra Horn
    March 15, 2010

    methotrexate isn't working for me what can I do now?

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FROM OUR EXPERTS

  • Lene  Andersen
    Health Guide
    March 16, 2010
    Lene  Andersen
    Health Guide
    March 16, 2010

    methotrexate can take up to two months to kick in, so if you're still waiting for it to take full effect, talk to your doctor about medication that can help you bridge the gap like e.g., prednisone. However, if you have been on methotrexate for a while and it's no longer helping, make an appointment to see your rheumatologist to discuss treatment options. The good news is that methotrexate is on the lower rungs of the ladder of treatments for RA, so there are lots of options that can help you.


FROM OUR COMMUNITY

  • melodie March 15, 2010
    melodie
    March 15, 2010

    Hi Sandra,  How long have you been on methotrexate? I didn't think it was working for me either. My RA Dr. said to give it 9 to 10 weeks. On the 9th week it did kick in. I am also on 5mg. of prednisone. I am alot better but still have a  few bad days. I hope you can find something that works for you. Make sure your Dr. knows how you are feeling. Hang in there!!  Melodie

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  • Judi March 19, 2010
    Judi
    March 19, 2010

    I have been on methotrexate  for years.  It did take several months before the benefit of it kicked in. Also, I started on a small dose and eventually had to go up to 10 - 2.5 mg. pills per week.  I am now back down to 4 pills per week but I am also on Enbrel, Plaquenil, Cyclobenzaprine, Clonazepam, Actonel and Lyrica. My diagnosis is Rheumatoid Arthritis, Fybromialgia, Osteo Arthritis and Osteoprosis.  For a number of years it was just R.A.  The combination of the medications seem to cut own on the number of flare ups that i have.  Your Doctor may need to try other medications or combinations of medications for you.  Good Luck.

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  • seroneg46 March 16, 2010
    seroneg46
    March 16, 2010

    Methotrexate took 4 months to work for me. Was just giving up hope then suddenly, day by day it took effect as I watched the inflammation on my knees go down

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  • BL
    BL
    February 06, 2012
    BL
    BL
    February 06, 2012

    Question: How can you tell if your methotrexate is working? I'm recently diagnosed and have been on methotrexate for 3 and 1/2 months, primarily for one joint, and that's still stiff, somewhat swollen and painful most of the time. Is that the usual experience? I'm on 20mg (8 pills) and the next step would probably be a biologic, so I'd like to have a better idea if I should try a different DMARD before going to injections.

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