My husband was diagnosed with RA about 9 months ago, and he is having a horrible time! He did ok on methotrexate for awhile, but then he had a terrible flare-up and his doctor prescribed Humira. So far he has had three shots, but the flares are continuing. Does anyone know how long it can take for Humira to work? He is SO depressed! It jumps around from hands to shoulders to feet to hips - its awful!