Hi,   Is your husband on any other arthritic medication to work with the Humira? I ave been on Humira, Arava, Celebrex to help combat my arthritis. He should start feeling the affects of the Humira by the next 2 shots. I did by my 5th shot. Everyone is different. If he is still in a bad flare up, his doctor should have helped him to ease the flare up along with putting him on Humira. You and your Husband should call your doctor back to help ease his flare ups while on waiting for the Humira to work. Maybe Humira is not right for him. Talk to his doctor for other options that might help him now and continue to help him in the future, as for the depression, that comes with the arthritis, talk to his doctor about that also, he can help.