I too have just been diagnosed with RA it is horrible I couldnt dress myself or go to the washroom by myself ,I am a fairly active person and within 2 months I was almost bed ridden. I started Humira 2 weeks ago and athough I still have pain and stiffness it has taken the edge off, the first day I noticed a small changed but thought that it was in my head because I wanted relief so bad. I get my second injection on wed and am very hopeful that I will feel a bit better again. my pharmacist said it can take up to 6 months to feel the full effect . I could not have survived that long in the agony I was in . I too was depressed and still am a bit . But I think it will get better. hang in there. If no one has it they really dont know how much PAIN you are in...