i noticed a difference instantly. not a significant difference...but i am 24 and have had RA since 4 years old and let me tell you i can actually clean my house and care for my 2 year old so that is how i know there is a difference. i live in rainy washington state so the weather kills me...but there have been several rainy days and i can function. i am also taking methotrexate, tramadol and percocet but i don't take pain med half the time because i cannot function with my child while i am on them. it is nice to read that others are feeling my pain. i was an aircraft mechanic for the military making extremely good money and lost it all a year ago because my RA has just become crippling. it is so hard to support a child with no income. also, i took enbrel and got stomach inflammation and extreme diahhrea from it. and a week ago i was also diagnosed with fibromyalgia...if i can keep going you can. yes, there are days i keep giong but i am relying on this little ray of hope that my doctor can find the right regimen of meds that will work for me. if i didn't have that hope and him telling me he is positive he can help me, and getting up each day with my child to live for, he gives me purpose. i think i would have killed myself had i not had such a magnificent child to live for.