I have just signed on here. I'm not even sure i've repleid properly. So here i am at 53 years old and i've had this RA since i was 30. It's a very long story so i won't go into that right now. But i'm on Methotrexate for the pas 15 years and had a small dose of cortisone (5 mg) a day, plus anti-inflammatory and pain killers. I went on Embrel a few years ago but it didn't work. Then Humira a year and a half ago. It worked within 3 days. I felt a new woman. But then i got a cold which turned into Bronchitis and i ended up going to hospital by ambulance with breathing stress. So i stopped the Humira. Since christmas i am suffering terrible with my left knee. So thought i should go back on Humira. I have had my 5th shot yesterday and strangely it isn't working at all. I live in France and it is almost 3 am and that's why i'm here because i'm suffering like mad. it's preventing me from sleeping. Doesn anyone know why Humira worked for me a year ago and why doesn't it work now. i'm so very peeved with this. I had accepted this illness and tried to get on with life, with 5 kids and a great husband. But now i am getting really depressed like in the beginning because i'm feeling that my life should be starting over with the kids grown and independant and it's all going wrong. I know i'm ranting but i'm so desperate. i've really appreciated what i've read here. I think there is a 3rd anti TNF (another type of Humira, Enbrel). I wonder if that would work. There doesn't seem to be a light at the end of this tunnel. Thanks for listening to my ramblings. By the way i live in France but i'm English.