I am 47 year old female and I was diagnosed back in year 2000 but never got treatment because I just dealth with the pain but this year and half I have become somewhat incapcitated. I walk with a limp, stairs kill me. Opening a bottle or a jar is excruitiating.  I started with metrotrexate pills but became ill with vomiting and bleeding through my nose. The next step was avara. I had terrible side effects, my nervous systems went crazy, blurred vision, swollen eyes, loss control of my nerves. Then I started metrotrexate injections .5mg weekly did not help, .8mg slight relief but my levels are still high. I started my first Humira injection this Saturday and I was totally surprised by the kick it had.  I am used to the burning sensation from the metrotrexate,  I too am desperate for it to work because I can't sleep for every bone in my body wreaks of pain. So you can't sleep so you are so tired and the depression and anxiety kicks in.  I pray for all of us to find some help and relief.  It saddens me that unfortunately it takes so much trial and error to find a medication that works for us.