I was given to understand that  if it was going to work then should see some signs of it doing so within 3 months! Am now 2 months in and  in the last few days my hands are definately less painful and the awfu nausea etc is beginning to wear off - whew!  My dose is 40 fortnightly so I think admittedly with out nowing your husband's dosage it might be time to reconsider, together with medical consultation wether it is worth continuing the drug. Have now got a sebacious something on my hand that has needed referral to dermatology, however give me that over RA any day.    Feel for both and hope all sorted soon.