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I lost a TON of hair when I first started taking the Methotrexate. But, I added a serious B Complex vitamin to the 5 mg of Folic Acid every day, and the hair loss stopped pretty quickly. Vitamen E can also help, if you aren't getting enough in your diet, and most of us don't. All the hair I lost is now growing back in - that's the really good thing. All of us loose about 100 hairs a day - that's normal. But more than that means you aren't getting enough of something in your system, and a good B Complex is a reasonable place to start. Hang in there!