I have been on Humira for 4 and a half months, along with MTX, Celebrex and Prednisone. Every time I try to get under 10 mg of prednisone, I end up with increased swelling and pain. I take 400 mgs of Celebrex a day and 300 mg of Tramadol for pain. I have been so determined to reduce the amount of meds I take every day, but I am now reconsidering my position on that matter. I just found out that my CRP level was a 7 and that put me in a high risk category for a heart attack. Humira has brought that level down to 3.5, and my RD is very, very happy about that. I had no idea this was even going on. I was a bit out of it my last visit. So.....I need to keep that inflammation down. I guess that is why my Rd has not said anything about decreasing any meds. She also just wrote another script for me for prednisone. Anyone have any experience/wisdom on inflammation they would like to share? I would be very interested in your experience and any suggestions you may have.