Hi, Lene,   Yes, I have a long, sordid history of reacting to meds in a way most people do not. Sigh.   I didn't sleep well last night, went into work an hour late.  My throat hurts a lot.  Been taking Tramadol and Celebrex and that helps the pain.  Now it looks like cottage cheese is back there in my throat. I'm thinking thrush, and perhaps strep throat because my throat is so red and sore.  I had Strep A once, and I had athsmus ulcers all over my mouth and tongue and throat.  I wonder...??? Then I have been having sinus headaches. Both of my docs are out until Monday, and I hate going to those walk-in clinics, but if it gets worse I will try to find one tomorrow.  I live in a rural area, but I could drive to Columbia where all the hospitals and doctors are, I guess.  They probably have an urgent care clinic open on Saturday.  I just want it to go away.  I think I'll go gargle with salt water.  No MTX for me tonight!   Thanks for your response.  I feel better just knowing that you know what is up. You understand these "werid" things.    V