hi V i was only on mtx for 2 weeks then my rheumy took me off of it he called the insurance company an said because of the bad side effects i caint take it surely your rheumy well do the same. the only reason they put us on mtx is because its cheap an been around longer. so if you caint take it im sure your rheumy can put you on something else.V i do beleive we are in a no win  with fatigue either the meds or the RA . i do think that it well be the way we are. i took off from work last friday slept almost all day an almost slept my weekend away . getting up this morning was so hard,im home now an want to go to sleep im so tired . this saturday i bearly scratch my arm an it had a red ring around it that has never happened before an it was very sore,its a little better now.i do believe that our roads have changed with taking the meds that they give us, every season well be something we will learn from an i hope other things dont get worse take care God Bless