Thanks for the info, Lene.  I am going to wait until I am past this virus thing, that is hanging on still for some reason.  My rheumy did increase my Celebrex to 200 mg twice a day instead of once a day.  Actually, I was supposed to be taking that much all along, but I was afraid to do it because of the cardiovascular issues, and I have had high bp for decades.  I finally decided to take it, and it has made a difference. I am just amazed at how fast RA is attacking my joints. I know I have had RA for a while, but it wasn't like it is now.  Now it seems out of control. I am ready to try the biologic.  My doctor was not happy when she examined my joints yesterda.  She wasn't happy to hear that I sleep all weekend either. That is when she said we had to have a "serious" talk. So...uncontrolled RA is more riskly than the meds, right Lene?  I'm a little scared.  I know what is right in my mind.  I just need to think of the meds as helping me and not worry about what "might" happen.    V